a b c Supplementary Figure 1

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a b c Supplementary Figure 1 Histological analysis of liver tissues from Adamts13-/- mice (panel a) and from Ad-ADAMTS13 treated mice sacrificed 1 week after injection (panel b and c). Liver specimens were fixed in formalin, embedded in paraffin, and 3 μm sections were stained with hematoxylin and eosin (original magnification, x 40). (a) Knockout mice had normal liver with well preserved architecture and absence of inflammatory infiltrate. (b and c) Sites of focal mixed inflammatory infiltrate were observed after adenoviral injection, mainly localized in the perivascular/pericentral areas and around the portal areas.