A, heatmap of copy number alterations determined by array CGH for a panel of 79 frozen NSCLC samples. A, heatmap of copy number alterations determined.

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A, heatmap of copy number alterations determined by array CGH for a panel of 79 frozen NSCLC samples. A, heatmap of copy number alterations determined by array CGH for a panel of 79 frozen NSCLC samples. Each row on the map represents analysis of a single tumor sample, and tumors are grouped by histology (52 squamous cell carcinoma and 27 adenocarcinoma, as indicated). Copy number gains and losses are indicated in red and green, respectively. B, FISH assay shows PIK3CA copy number gains in a representative NSCLC tumor sample. Chromosomal copies of PIK3CA are shown in red, and the centromeric control gene CEP3 is shown in green. The PIK3CA/CEP3 ratio determines whether copy number variation is because of gene amplification or polysomy. C, scatter plot of PIK3CA/CEP3 ratios as determined by FISH for 84 FFPE tumor samples. Each point represents the ratio from a single tumor sample grouped by histology. The horizontal line represents the mean ratio ± SE. D, comparison of the PIK3CA/CEP3 ratio in matched primary and metastatic NSCLC samples. Jill M. Spoerke et al. Clin Cancer Res 2012;18:6771-6783 ©2012 by American Association for Cancer Research