Expansion of omental FRCs and FALC remodeling after intraperitoneal exposure to bacterial antigen. Expansion of omental FRCs and FALC remodeling after.

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Expansion of omental FRCs and FALC remodeling after intraperitoneal exposure to bacterial antigen. Expansion of omental FRCs and FALC remodeling after intraperitoneal exposure to bacterial antigen. (A to C) Confocal microscopic analysis of FALCs on day 4 after immunization with S. Typhi OmpC/F. (A) Microscopic structure of omental FALCs from Ccl19-EYFP mice (top) and mice lacking MYD88 expression in FRCs (bottom) using the indicated markers. Representative image from one of four mice per group. Scale bar, 100 μm. Number of FALCs per square millimeter (B) and percentage of FALC-covered area in the omentum (C). Relative frequency (D) and absolute numbers (E) of PDPN+EYFP+ cells in the omentum of the indicated mouse strains on day 4 after immunization with S. Typhi OmpC/F or in untreated mice (naive); bars represent mean values ± SEM. Enumeration of CD11b+ myeloid cells (F), B220+ B cells (G), and B cell populations (H) on day 4 after immunization in mice lacking MYD88 expression in FRCs or in Cre-negative littermates (Ctrl). Data in (B) to (H) represent mean values ± SEM and are from four to nine mice per group from two to three independent experiments; statistical analysis was performed using one-way ANOVA with Dunnett’s multiple comparison test (D and E) or Student’s t test (B, C, and F to H). *P < 0.05, **P < 0.01, and ***P < 0.001. Christian Perez-Shibayama et al. Sci. Immunol. 2018;3:eaar4539 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works