Nucleophilic Substitution: Alkylation of α Carbons

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Presentation transcript:

Nucleophilic Substitution: Alkylation of α Carbons

Determining Thermodynamic Enolate

Determining Kinetic Enolate

Polyhalogenation of α Carbons under basic conditions

Formation of Ethers

Williamson’s Ether Synthesis Green Principles Addresses Less Hazardous Reagents Safer Solvent Use of renewable feedstocks

Intramolecular Williamson Ether Syntheses

Reactions of Epoxides under Neutral and Basic Conditions

Reactions of Epoxides under Neutral and Basic Conditions (cont)

Reactions of Epoxides under Neutral and Basic Conditions (cont) 67_p549_Karty1_CH10

Reactions of Epoxides under Neutral and Basic Conditions (cont) 68_p549_Karty1_CH10

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