W. chinensis extract attenuates tumor growth of 103E (a subline of CWR22Rv1) engrafted in the prostate of nude mice. W. chinensis extract attenuates tumor.

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W. chinensis extract attenuates tumor growth of 103E (a subline of CWR22Rv1) engrafted in the prostate of nude mice. W. chinensis extract attenuates tumor growth of 103E (a subline of CWR22Rv1) engrafted in the prostate of nude mice. Orthotopic 103E tumor xenografts were established in nude mice and mice were treated with W. chinensis extract via oral gavage once daily for 28 d. A, bioluminescence intensities in each treatment group were measured weekly and are presented as growth curves. Points, mean (n = 7); bars, SE. B, representative photograph of dissected tumors of all tested groups. C, endpoint mass of implanted tumors, including adherent seminal vesicle at the implantation site, were weighed and plotted and then analyzed for significant difference. Columns, mean (n = 7); bars, SE. Each treatment group was compared with control (t test). *, P ≤ 0.05; **, P ≤ 0.01. D, mean body weight for each treatment group as a function of day of treatment. Chin-Hsien Tsai et al. Clin Cancer Res 2009;15:5435-5444 ©2009 by American Association for Cancer Research