Plasma concentration-time profile after oral administration of a single dose. Plasma concentration-time profile after oral administration of a single dose.

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Plasma concentration-time profile after oral administration of a single dose. Plasma concentration-time profile after oral administration of a single dose. The components relevant to the pharmacokinetics of a drug’s concentration-time profile are the peak or maximum plasma concentration (Cmax) and the time when it occurs (Tmax), the area under the concentration-time curve (represented as shaded area), and the elimination t1/2 (determined using the blue lines). Tom N. Lea-Henry et al. CJASN 2018;13:1085-1095 ©2018 by American Society of Nephrology