Mechanism by which flavopiridol induces cell cycle arrest and apoptosis in rhabdoid tumor cells. Mechanism by which flavopiridol induces cell cycle arrest.

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Mechanism by which flavopiridol induces cell cycle arrest and apoptosis in rhabdoid tumor cells. Mechanism by which flavopiridol induces cell cycle arrest and apoptosis in rhabdoid tumor cells. A and B, percentage of MON (A) and G401 (B) cells at sub-G1 when treated for 48 h with flavopiridol in the presence of a pan-caspase inhibitor, z-VAD-FMK (CTRL, control not treated with caspase inhibitor; CI, caspase inhibitor). C and D, kinetics of caspase 3/7 activation in MON (C) and G401 (D) cells treated with the indicated concentrations of flavopiridol (in nmol/L; F, flavopiridol; CTRL, control vehicle). E, immunoblot analysis of various cell cycle proteins after 48 h of treatment with the indicated concentrations of flavopiridol. Melissa E. Smith et al. Clin Cancer Res 2008;14:523-532 ©2008 by American Association for Cancer Research