Depleting NQO1 expression levels inhibits growth of NSCLC cells in soft agar. Depleting NQO1 expression levels inhibits growth of NSCLC cells in soft agar.

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Depleting NQO1 expression levels inhibits growth of NSCLC cells in soft agar. Depleting NQO1 expression levels inhibits growth of NSCLC cells in soft agar. A, A549 shCtr-R and A549 shNQO1 cells were analyzed for their ability to form colonies and grow in soft agar. Photomicrographs shown are representative of experiments performed in sextuplet. B–D, graphical representation of enumerated colonies for A549 shNQO1, A549 shNQO1-B, and H292 shNQO1-B cells versus A549 shCtr-R, A549 shCtr-L, and H292 shCtr-L cells. B, P values for A549 shNQO1 versus A549 shCtr-R (P < 0.0001). C, P values for A549 shNQO1-B versus A549 shCtr-L (P = 0.0041). D, P values for H292 shNQO1-B versus H292 shCtr-L (P = 0.0114). Brian Madajewski et al. Mol Cancer Res 2016;14:14-25 ©2016 by American Association for Cancer Research