George E. Sarris, MDa, Kathleen A. Moore, BSa, John S

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Presentation transcript:

Cardiac transplantation: The Stanford experience in the cyclosporine era George E. Sarris, MDa, Kathleen A. Moore, BSa, John S. Schroeder, MDb, Sharon A. Hunt, MDb, Michael B. Fowler, MDb, Hannah B. Valantine, MDb, Randall H. Vagelos, MDb, Margaret E. Billingham, MDc, Philip E. Oyer, MD, PhDa, Edward B. Stinson, MDa, Bruce A. Reitz, MDa, Norman E. Shumway, MD, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 108, Issue 2, Pages 240-252 (August 1994) DOI: 10.5555/uri:pii:S0022522394700060 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Distribution of recipient diagnoses. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Age distribution of the recipient and donor patient populations. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Causes of operative (A) and overall deaths (B). The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Causes of operative (A) and overall deaths (B). The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Actuarial survival for the entire patient population. Error bars in this and all figures represent ±1 standard error of the mean. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 5 Actuarial freedom from rejection for the entire group of patients. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 6 Linearized rejection rates for current protocol (group I) and all other patients. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 7 Actuarial freedom from rejection-related death for the entire group of patients. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 8 Actuarial freedom from infection (A) and from infection-related death (B) for all patients. C, Actuarial freedom from infection with the major classes of pathogens. D, Actuarial freedom from infection for patients operated on before and after 1987. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 8 Actuarial freedom from infection (A) and from infection-related death (B) for all patients. C, Actuarial freedom from infection with the major classes of pathogens. D, Actuarial freedom from infection for patients operated on before and after 1987. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 8 Actuarial freedom from infection (A) and from infection-related death (B) for all patients. C, Actuarial freedom from infection with the major classes of pathogens. D, Actuarial freedom from infection for patients operated on before and after 1987. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 8 Actuarial freedom from infection (A) and from infection-related death (B) for all patients. C, Actuarial freedom from infection with the major classes of pathogens. D, Actuarial freedom from infection for patients operated on before and after 1987. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 9 Actuarial freedom from graft CAD (A) from CAD-related death (B), and from CAD-related death or retransplantation (C). D, Actuarial freedom from graft CAD according to donor age. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 9 Actuarial freedom from graft CAD (A) from CAD-related death (B), and from CAD-related death or retransplantation (C). D, Actuarial freedom from graft CAD according to donor age. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 9 Actuarial freedom from graft CAD (A) from CAD-related death (B), and from CAD-related death or retransplantation (C). D, Actuarial freedom from graft CAD according to donor age. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 9 Actuarial freedom from graft CAD (A) from CAD-related death (B), and from CAD-related death or retransplantation (C). D, Actuarial freedom from graft CAD according to donor age. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 10 Renal function parameters remained relatively stable after an initial decline early after the operation. BUN, Blood urea nitrogen. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 11 Blood pressure (BP) rises early after transplantation but remains stable thereafter. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 12 Doses over time of the three primary immunosuppressive agents used. CYA, Cyclosporine; Pred, prednisone; AZA, azathioprine. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 240-252DOI: (10.5555/uri:pii:S0022522394700060) Copyright © 1994 Mosby, Inc. Terms and Conditions