Marking Emerging β- and γδ-Selected T Cells Cornelis Murre  Immunity  Volume 24, Issue 1, Pages 11-13 (January 2006) DOI: 10.1016/j.immuni.2005.12.004 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Model Outlining Early Regulatory Events in Emerging β- and γδ-Selected T Lineage Cells Regulation of transcription factors in emerging β- and γδ-selected T cells. Upon pre-TCR-mediated signaling, Id3 expression is elevated in DN3b cells, whereas that of HEB transcripts are decreased and E47 abundance is lowered as a direct result of both Id3 inhibition and signaling through the TCR, ultimately resulting in a decrease in E protein DNA binding activity. In emerging γδ T cells, the expression of Egr2, Egr3, and Id3 is increased, whereas that of HEB transcripts are lowered. Immunity 2006 24, 11-13DOI: (10.1016/j.immuni.2005.12.004) Copyright © 2006 Elsevier Inc. Terms and Conditions