VEGF-A inhibition impedes proliferation in Amppos tumors.

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VEGF-A inhibition impedes proliferation in Amppos tumors. VEGF-A inhibition impedes proliferation in Amppos tumors. Mdr2−/− mice were treated with adenovectors expressing either GFP alone or GFP and sFLT for 10 days. A, representative photomicrographs of IHC for BrdUrd. Tumor-infiltrating cells remain proliferative. Scale bar, 100 μm. B, BrdUrd immunostaining was quantified using automated image analysis (n ≥ 6; *, P < 0.05). C, mRNA qPCR analysis of the indicated genes in Ampneg and Amppos tumors treated with the indicated adenovectors. Each dot represents a different tumor. The cross line signifies geometric mean (***, P < 0.0001). D, left, histologic section stained with H&E depicting necrosis, representing three out of the six sFLT-treated Amppos tumors. Scale bar, 500 μm. Right, a macroscopic picture of a tumor with hemorrhagic necrosis. Scale bar, 0.5 cm. Elad Horwitz et al. Cancer Discovery 2014;4:730-743 ©2014 by American Association for Cancer Research