The influence of asthma control on the severity of virus-induced asthma exacerbations David J. Jackson, MRCP, PhD, Maria-Belen Trujillo-Torralbo, BSc,

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Presentation transcript:

The influence of asthma control on the severity of virus-induced asthma exacerbations David J. Jackson, MRCP, PhD, Maria-Belen Trujillo-Torralbo, BSc, Jerico del-Rosario, BSc, Nathan W. Bartlett, PhD, Michael R. Edwards, PhD, Patrick Mallia, MRCP, PhD, Ross P. Walton, PhD, Sebastian L. Johnston, FRCP, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 2, Pages 497-500.e3 (August 2015) DOI: 10.1016/j.jaci.2015.01.028 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The response to rhinovirus infection in asthma according to baseline control status. Daily upper (A) and lower (B) respiratory tract symptoms are shown over the 14 days postinoculation with rhinovirus. The daily lower respiratory tract scores have been corrected for baseline symptoms and any effect of bronchoscopy. The total lower respiratory tract symptom score is the summation of the daily scores over 14 days (C) and the maximal fall in FEV1 (as a percentage change from baseline) (D) are shown for all subjects according to the ACQ score group. The total lower respiratory tract symptom score is also shown according to asthma severity (E), with the relationship between ACQ score and total lower respiratory tract symptoms shown for those with moderately severe asthma only (F). Results shown as lines are mean values (Fig 1, A-E). Statistically significant differences shown in A and B refer to differences across all groups (1-way ANOVA). Clinical data are missing for 1 patient with well-controlled asthma (n = 11). *P < .05; **P < .01; ***P < .001. Journal of Allergy and Clinical Immunology 2015 136, 497-500.e3DOI: (10.1016/j.jaci.2015.01.028) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions