Small RNA (smRNA) profiles in plasma of tuberculosis (TB) infected individuals before and after treatment. a–d) Wilcoxon paired analysis of plasma smRNA.

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Presentation transcript:

Small RNA (smRNA) profiles in plasma of tuberculosis (TB) infected individuals before and after treatment. a–d) Wilcoxon paired analysis of plasma smRNA concentration (6–150 nucleotides) before (day 0) and after (week 24) anti-TB treatment for individuals w... Small RNA (smRNA) profiles in plasma of tuberculosis (TB) infected individuals before and after treatment. a–d) Wilcoxon paired analysis of plasma smRNA concentration (6–150 nucleotides) before (day 0) and after (week 24) anti-TB treatment for individuals with active TB. a) Individuals who were culture negative at week 24 (n=30) and b) who were culture positive at week 24 (n=4). smRNA according to HIV status: c) HIV-negative individuals; and d) HIV co-infected individuals. ns: nonsignificant. e, f) Fold change for four individual smRNA genes at day 0 (pretreatment) compared with week 24 (after treatment) in those that culture converted by week 24 (circles, n=30) compared with those who were culture-positive at week 24 (triangles, n=4). p-values are uncorrected. #: indicates statistical significance after Bonferroni correction. Grey symbols: HIV-negative; black symbols: co-infected with HIV-1, antiretroviral therapy naïve; white symbols: co-infected with HIV-1, receiving antiretroviral therapy. g) Cluster diagram using the four individually tested microRNA species (miR-29a, 17-3p, 133a, and SNORD61). (+): indicates those who were culture-positive after treatment completion. Isobella Honeyborne et al. Eur Respir J 2015;45:1741-1744 ©2015 by European Respiratory Society