Global analysis of the chemical–genetic interaction map.

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Global analysis of the chemical–genetic interaction map. Global analysis of the chemical–genetic interaction map. A, comparison of chemical–genetic interactions from this study at a variety of significance cutoffs with 489 drug–gene associations spanning 21 genes and 40 drugs identified in the Cancer Genome Project (CGP) study through regression analysis (P value of 0.05; ref. 4). The score cutoff reflects the absolute value of the S-score, and therefore encapsulates both resistance and sensitivity. Dotted line represents background probability of overlap. B, a genetic interaction profile for each drug is calculated across 51 cell lines. Using a sliding cutoff based on correlation of profiles, the similarity of genetic interaction profiles for two drugs is plotted against the fraction of these drugs that have the same annotated molecular target. C, hierarchical clustering of drug profile similarities for compounds targeting multiple distinct biologic pathways. Maria M. Martins et al. Cancer Discov 2015;5:154-167 ©2015 by American Association for Cancer Research