Frequency and number of KLL-specific clonotypes in tumors from patients with KLL-specific T cells in PBMCs or cultured TILs. A wedge (the length of which.

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Frequency and number of KLL-specific clonotypes in tumors from patients with KLL-specific T cells in PBMCs or cultured TILs. A wedge (the length of which represents the total number of productive unique clonotypes in each tumor) is indicated for each tumor ... Frequency and number of KLL-specific clonotypes in tumors from patients with KLL-specific T cells in PBMCs or cultured TILs. A wedge (the length of which represents the total number of productive unique clonotypes in each tumor) is indicated for each tumor on a log scale. Each tumor is identified by patient “w” or “z” number and type of tumor. Tumors from 11 of 12 patients were analyzed; no tumor could be acquired for patient w750. Primary tumor from w782 was small and LN was analyzed to ensure adequate sampling. KLL-specific clonotypes (white) are depicted within each tumor with a width approximately proportional to their frequency within each tumor. More predominant clonotypes are located to the left for each tumor. The number of KLL-specific clonotypes out of the total number of unique clonotypes is tabulated at far right. Wedges for tumors from patients alive at time of censoring are in black, and wedges for tumors in gray are from patients who have died of MCC. UP = unknown primary, Met = distant metastasis. Natalie J. Miller et al. Cancer Immunol Res 2017;5:137-147 ©2017 by American Association for Cancer Research