Fig. 4 A novel peptidomimetic (AV3) against ITGA5.

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Fig. 4 A novel peptidomimetic (AV3) against ITGA5. A novel peptidomimetic (AV3) against ITGA5. (A) Chemical structure of AV3 peptidomimetic. (B) Binding of AV3-FAM in control hPSCs, TGF-β–activated hPSCs, and sh-ITGA5 hPSCs, as shown in the representative microscopic fluorescent images and quantitative analysis from flow cytometry. (C and D) Immunocytochemical staining and Western blot analyses show that AV3 inhibits α-SMA and collagen I expression levels in hPSCs, whereas scrambled (s)AV3 shows no inhibitory effects. (E) Bar graph showing the results from the collagen gel assay in which AV3 inhibits TGF-β–induced collagen gel contractility after 72 hours. (F) Western blot analyses showing the expression levels of pFAK, FAK, and β-actin in hPSCs following AV3 treatment of TGF-β–activated hPSCs for 8 hours. (G) Representative images of PANC-1 + hPSC (A) and MIA PaCa-2 + hPSC (H) heterospheroids. The graph shows the spheroid volume and cell viability after the treatment with AV3 and cotreatment with AV3 and gemcitabine compared to either vehicle- or gemcitabine-treated spheroids. Data represent means ± SEM from at least three independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001. Praneeth R. Kuninty et al. Sci Adv 2019;5:eaax2770 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).