The Regulatory T Cell Transcriptosome: E Pluribus Unum

Slides:

Advertisements

Similar presentations

How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages (November 2011) DOI: /j.immuni

Advertisements

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Meghan A. Koch, Kerri R. Thomas, Nikole R.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,

Copyright © 2015 by the American Osteopathic Association.

“Toll”-erance in the Skin

Chapter 08 The T Cell Receptor: Proteins and Genes

Of Worms and Men: HLH-30 and TFEB Regulate Tolerance to Infection

Connecting COX-2 and Wnt in cancer

CD5: A New Partner for IL-6

HIV-1 Latency by Transition

EMT: Matter of Life or Death?

Tolloid gets Sizzled Competing with Chordin

The Leptin Connection: Regulatory T Cells and Autoimmunity

Tendon Homeostasis: The Right Pull

Why Is There so Much CD45 on T Cells?

The Ids Have It Cancer Cell

Volume 29, Issue 5, Pages (November 2008)

Toll-like Receptor 9, What O'Clock Is It?

Notch: Filling a Hole in T Helper 2 Cell Differentiation

Mind Bomb Proteins in the Antiviral Arsenal

IL-33 Raises Alarm Immunity Volume 31, Issue 1, Pages 5-7 (July 2009)

T Helper 17 Cells Get the NOD

Unraveling the Pros and Cons of Interferon-γ Gene Regulation

Kaitlin A. Read, Michael D. Powell, Paul W. McDonald, Kenneth J

PU.1 Takes Control of the Dendritic Cell Lineage

Foxo1 and Foxo3 help Foxp3 Immunity

Volume 142, Issue 4, Pages (August 2010)

BMP Signaling Goes Posttranscriptional in a microRNA Sort of Way

MicroRNAs in Tfh Cells: Micromanaging Inflammaging

A New Twist in Smad Signaling

Volume 46, Issue 5, Pages (June 2012)

Computing at the Front-End by Receptor Networks

Volume 26, Issue 3, Pages (March 2007)

E Proteins Enforce Security Checkpoints in the Thymus

BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens

Connecting Mitochondria and Innate Immunity

14-3-3ζ Turns TGF-β to the Dark Side

Targeting Smads to Restore Transforming Growth Factor-β Signaling and Regulatory T- Cell Function in Inflammatory Bowel Disease Deanna D. Nguyen, Scott.

T Cells Are Smad’ly in Love with Galectin-9

Why Worms Watch Their Hemidesmosomes and Why You Should, Too

Silencing Insulin Resistance through SIRT1

Gene Regulation: Hacking the Network on a Sugar High

The RAS/MAPK Axis Gets Stressed Out

Hippo: Hungry, Hungry for Melanoma Invasion

Glia: Regulating Synaptogenesis from Multiple Directions

Superficial Immunity: Antimicrobial Responses Are More Than Skin Deep

p38δ and PKD1: Kinase Switches for Insulin Secretion

The Dual Role of Bone Morphogenetic Proteins in Cancer

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

Mark S. Sundrud, Anjana Rao Immunity

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

Cytokine Signaling Modules in Inflammatory Responses

Peter Libby, Amélie Vromman Immunity

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases Xiaoyu Hu, Lionel B. Ivashkiv Immunity

Licensing PPARγ to Work in Macrophages

Recycling Endosomes and TLR Signaling— The Rab11 GTPase Leads the Way

Regulatory T Cells GATA Have It

Daniel L. Northrup, Keji Zhao Immunity

Volume 24, Issue 1, Pages 7-8 (July 2016)

At 17, In-10's Passion Need Not Inflame

Biological Functions of Activity-Dependent Transcription Revealed

PTENtiating CFTR for Antimicrobial Immunity

Identity Crisis: It’s Not Just Foxp3 Anymore

Why Worms Watch Their Hemidesmosomes and Why You Should, Too

Marking Emerging β- and γδ-Selected T Cells

IL-9 by INFERence Immunity

Skp2, the FoxO1 hunter Cancer Cell

Presentation transcript:

The Regulatory T Cell Transcriptosome: E Pluribus Unum Talal Chatila Immunity Volume 27, Issue 5, Pages 693-695 (November 2007) DOI: 10.1016/j.immuni.2007.11.004 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Positive Reinforcement of Foxp3 and TGF-β-Dependent Circuits TGF-β signaling at its heterodimeric receptor (TGF-βRI–TGF-βRII) results in the phosphorylation of the TGF-β-regulated transcriptional activators Smad2 and Smad3 proteins, their association with Smad4, and translocation to the nucleus. Smad-dependent induction of Foxp3 in turn reinforces TGF-β-dependent gene expression, including the transcription of TGF-βRI. A proposed mechanism involves the promotion by Foxp3 of Smad protein retention in the nucleus. Immunity 2007 27, 693-695DOI: (10.1016/j.immuni.2007.11.004) Copyright © 2007 Elsevier Inc. Terms and Conditions