Venn diagram showing the overlap of PD-L1 overexpression, MSI-NGS–high, and TML-high in all gastrointestinal tumors, with all three markers tested (N = 3,896). Venn diagram showing the overlap of PD-L1 overexpression, MSI-NGS–high, and TML-high in all gastrointestinal tumors, with all three markers tested (N = 3,896). N indicates the number of cases within each category. A total of 3,408 tumors were negative for all three markers. Mohamed E. Salem et al. Mol Cancer Res 2018;16:805-812 ©2018 by American Association for Cancer Research