Week 7a: Action Potential Part 2: Spike patterning

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Presentation transcript:

Week 7a: Action Potential Part 2: Spike patterning BIOL3833 Week 7a: Action Potential Part 2: Spike patterning

The Plan Today: Brief lecture: Action potential patterning (~20 minutes) Begin simulations for homework 4 (remainder of class)

Advanced ion channels Delayed-rectifier K+ channels (gK) A-type K+ channels (gA) M-type K+ channels (gM) AHP channels (gAHP) BK channels (gC) T-type Ca2+ channels (pT) L-type Ca2+ channels (pL)

Action potential frequency and patterning Spike frequency adaptation Dynamic range & intensity coding Multiple operational modes

Spike frequency adaptation

Why is spike frequency adaptation important? Filtering out responses to things that aren’t changing

Spike frequency adaptation is very plastic

Dynamic range Dynamic range refers to the range of firing frequencies that a neuron can produce as their excitatory inputs increase.

Saturation Dynamic Range Subthreshold

Why dynamic range is important

Dynamic range and spike frequency adaptation in sensory systems

Encoding visual information in the brain:

Thalamic relay neurons have multiple modes Transfer mode Multiple spikes Wide dynamic range Awake / High arousal Burst mode Slow rhythmic firing Terrible dynamic range Asleep / Low arousal -55 mV -65 mV -75 mV

Why? To transmit sensory information to the sensory cortex when we are awake, but to block that transmission when we sleep.

Disorders of thalamic relay neuron states Absence seizures Disorders of thalamic relay neuron states What happens when these neurons slip into burst mode when they shouldn’t?