Long-term studies of the natural history of asthma in childhood

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Staphylococcus aureus sensitization and allergic disease in early childhood: Population- based birth cohort study Aida Semic-Jusufagic, MD, Claus Bachert,

What drives prescription patterns in pediatric asthma management?

The natural history of soy allergy

Genetic influence on the age at onset of asthma: A twin study

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Risk of an asthma exacerbation after bariatric surgery in adults

Asthma exacerbations: Origin, effect, and prevention

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD

Is 9 more than 2 also in allergic airway inflammation?

Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial Marko Kalliomäki, MD, PhD,

Children with allergic and nonallergic rhinitis have a similar risk of asthma Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age Hans Bisgaard, MD,

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study Asger Sverrild, MD, Celeste Porsbjerg,

No evidence of intrauterine sensitization against inhalant allergens

Rising prevalence of asthma is sex-specific in a US farming population

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

Etiology of asthma exacerbations

Prenatal and postnatal genetic influence on lung function development

Pet exposure and risk of atopic dermatitis at the pediatric age: A meta-analysis of birth cohort studies Claudio Pelucchi, ScD, Carlotta Galeone, PhD,

Daniel J. Jackson, MD, James E. Gern, MD, Robert F. Lemanske, MD

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life

Reply Journal of Allergy and Clinical Immunology

An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma Ingo Marenholz, PhD, Tamara Kerscher,

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults Meghan F. Davis, PhD, Roger D. Peng, PhD,

What are the best outcome measurements for atopic eczema

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study Asger Sverrild, MD, Celeste Porsbjerg,

CDHR3 gene variation and childhood bronchiolitis

Endotyping early childhood asthma by quantitative symptom assessment

Michelle Daya, PhD, Kathleen C. Barnes, PhD

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Diagnosis and management of early asthma in preschool-aged children

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Matthew J. Loza, PhD, Bao-Li Chang, PhD

One step forward, 2 steps back: The enigma of preschool wheeze

The impact of a history of asthma on long-term outcomes of people with newly diagnosed chronic obstructive pulmonary disease: A population study Tetyana.

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

The Editors' Choice Journal of Allergy and Clinical Immunology

Day-care attendance, position in sibship, and early childhood wheezing: A population- based birth cohort study Nicolaos C. Nicolaou, MD, MPhil, Angela.

The relationship between vaccine refusal and self-report of atopic disease in children Rachel Enriquez, PhD, Whitney Addington, MD, Faith Davis, PhD,

Asthma progression: Can we and should we measure it?

Atopic endotype in childhood

Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis Elizabeth T. Jensen,

The Editors' Choice Journal of Allergy and Clinical Immunology

Macrolide antibiotics and asthma treatment

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Asthma: The past, future, environment, and costs

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization.

Environmental factors and eosinophilic esophagitis

Paradoxical psoriasis following anti–TNF therapy in ankylosing spondylitis: A population- based cohort study Jung Min Bae, MD, PhD, Hyuck Sun Kwon, MD,

Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants Charlotte Giwercman, MD, Liselotte.

Negative affect, medication adherence, and asthma control in children

Association between varicella zoster virus infection and atopic dermatitis in early and late childhood: A case-control study Jonathan I. Silverberg,

Natural history of cow’s milk allergy

The Editors’ Choice Journal of Allergy and Clinical Immunology

Primary prevention of asthma and allergy

Ann-Marie M. Schoos, MD, PhD, Bo L

Presentation transcript:

Long-term studies of the natural history of asthma in childhood Hans Bisgaard, MD, DMSc, Klaus Bønnelykke, MD, PhD Journal of Allergy and Clinical Immunology Volume 126, Issue 2, Pages 187-197 (August 2010) DOI: 10.1016/j.jaci.2010.07.011 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Genetic variants might define novel endophenotypes with different underlying mechanisms. Close clinical symptom monitoring in the COPSAC birth cohort suggested that FLG and ORMDL3 variants define 2 distinct endophenotypes. The logarithmic regression lines were calculated from the observed relative risks previously published.36,41A, FLG-associated endophenotype characterized by very early onset of eczema, followed by acute severe asthmatic exacerbations and later development of sensitization.41B, ORMDL3-associated endophenotype (rs7216389) characterized by a strong effect on early development of recurrent wheeze with acute severe asthmatic exacerbations but no effects on eczema or allergic sensitization.36Red line, eczema; blue line, acute severe asthmatic exacerbations; green line, allergic sensitization. Journal of Allergy and Clinical Immunology 2010 126, 187-197DOI: (10.1016/j.jaci.2010.07.011) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Risk of recurrent wheeze. COPSAC showed a strong association between colonization of the airways with common pathogenic bacteria and development of recurrent wheeze and asthma.63 The close clinical monitoring of age of onset for exposure and outcome allows survival statistics as a powerful statistical tool, as illustrated here by the inverse Kaplan-Meier plot. Copyright 2007 New England Journal of Medicine. Journal of Allergy and Clinical Immunology 2010 126, 187-197DOI: (10.1016/j.jaci.2010.07.011) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions