Sugar Makes Fat by Talking to SCAP Wei Shao, Peter J. Espenshade  Cancer Cell  Volume 28, Issue 5, Pages 548-549 (November 2015) DOI: 10.1016/j.ccell.2015.10.011 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Glucose-Induced Activation of SREBP and Lipogenesis Glucose promotes lipogenesis by (1) generating acetyl-CoA, the substrate for lipogenesis; (2) stimulating pancreatic insulin secretion, which activates SREBP-dependent lipogenic gene expression; and (3) generating UDP-GlcNAc required for SCAP N-glycosylation. Glycosylation of SCAP prevents its degradation and promotes disassociation from the ER-resident protein INSIG, resulting in SREBP activation. Abbreviations: INSIG, insulin-induced gene; UDP-GlcNAc; uridine diphosphate N-acetylglucosamine; acetyl-CoA, acetyl coenzyme A. Cancer Cell 2015 28, 548-549DOI: (10.1016/j.ccell.2015.10.011) Copyright © 2015 Elsevier Inc. Terms and Conditions