A Neural Protection Racket: AMPK and the GABAB Receptor

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A Neural Protection Racket: AMPK and the GABAB Receptor D. Grahame Hardie, Bruno G. Frenguelli Neuron Volume 53, Issue 2, Pages 159-162 (January 2007) DOI: 10.1016/j.neuron.2007.01.004 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Upstream Activators and Downstream Effectors of AMPK in Neurons under Stress AMPK is activated either by a rise in Ca2+-activating CaMKKβ, which triggers phosphorylation of AMPK, or by metabolic stresses that deplete ATP and increase AMP, leading to inhibition of AMPK dephosphorylation, which opposes the effect of either LKB1 or CaMKKβ. Activated AMPK phosphorylates the R2 subunit of the GABAB receptor, promoting the ability of GABA to activate postsynaptic K+ channels via Gi/Go. Phosphorylation of the receptor may also cause increased GABA-dependent inhibition of presynaptic Ca2+ channels, although that has not yet been directly demonstrated. Neuron 2007 53, 159-162DOI: (10.1016/j.neuron.2007.01.004) Copyright © 2007 Elsevier Inc. Terms and Conditions