Endoluminal Closure Device February 6, 2006 Braham Dhillon Ali Hales Laura Mattaliano John Sticklen John

Problem Statement: Close Gastrotomy Incision John

NOTES: Natural Orifice Transluminal Endoscopic Surgery Using an endoscope, create a gastrotomy to gain access to peritoneal cavity to perform surgery JPStick

Endoscope Laura

Design Parameters Endoscope Incision Port Diameter Length: 110 cm One Channel: 2.2-4.2mm Two Channels: 2.8/3.4mm Length: 110 cm Incision Length: 2 cm Stomach wall thickness: 3-5 mm Heal within 7-14 days Laura

Nitinol Mixture of nickel and titanium Thermal Shape Memory Shape dependent on temperature Biocompatibility Several FDA approved devices High corrosion resistance Intermetallic, not an alloy Bonding force between nickel and titanium strong Elastic Deployment Pass through narrow canal Return to original shape Laura

Current Design Ideas: Nitinol Coil Braham

Current Designs Ideas: Suturing Mechanism (based on Bard EndoCinch Suturing System) 1 2 3 Braham 4 5 http://medicine.iupui.edu/heartburn/endocinch.html

Current Design Ideas: “Dhillon’s Grab & Pull” Braham

Heart Patch CardioSEAL® AMPLATZER® Braham The AMPLATZER® device consists of two wire mesh discs filled with polyester fabric (see photo above). When the device is in proper position, the device is slowly pushed out the catheter until the discs of the device sit on each side of the hole (like a sandwich). The CardioSEAL® device consists of small double umbrella arms attached to Dacron fabric (see photo above), with special springs. When the device is in proper position, the device is slowly pushed out of the special catheter, the umbrella springs open, and covers each side of the hole (like a sandwich). CardioSEAL® AMPLATZER® www.clevelandclinic.org/heartcenter/ pub/guide/tests/procedures/closuredevice.htm

Accessories Braham Typical accessory device Forceps pictured here

Current Accomplishments Contacted Dr. Wittig Access to Nitinol Determined the final dimensions of endoscope Scheduled appointment with Dr. Holzman Patent Search Hales

Current Plan Dr. Holzman Meeting Develop prototype Today, 4pm Discuss design options and determine final design to work with Determine Final Budget Develop prototype Materials Exact Dimensions Hales

Future Plans Develop functioning prototype Ordering Necessary materials Requesting access to necessary equipment Determine methods of testing procedure - Materials with properties of stomach - Testing on animal stomachs Hales

Questions?

References www.gensurg.co.uk ntroi.stanford.edu http://medicine.iupui.edu/heartburn/endocinch.html