Drugs that target the prostacyclin pathway and their routes of administration. #: approved only by the US Food and Drug Administration; ¶: approved only in Japan and South Korea; +: approved only in New Zealand; §: this pump is under investigation and is no... Drugs that target the prostacyclin pathway and their routes of administration. #: approved only by the US Food and Drug Administration; ¶: approved only in Japan and South Korea; +: approved only in New Zealand; §: this pump is under investigation and is not approved in the USA or Europe. Reproduced from [16] with permission from the publisher. Harrison W. Farber, and Wendy Gin-Sing Eur Respir Rev 2016;25:418-430 ©2016 by European Respiratory Society