53BP1 Goes Back to Its p53 Roots

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53BP1 Goes Back to Its p53 Roots Daniel Durocher, Laurence Pelletier Molecular Cell Volume 64, Issue 1, Pages 3-4 (October 2016) DOI: 10.1016/j.molcel.2016.09.024 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Model of 53BP1 Action in Promoting p53 Activity 53BP1 acts in the nucleoplasm as a scaffold linking USP28 to p53. The USP28 deubiquitylase activity promotes the conversion of an inactive form of p53 into an active protein competent for DNA binding. Inducers of p53-dependent responses such as genotoxic insults or centrosome imbalance signal independently of 53BP1 action. Molecular Cell 2016 64, 3-4DOI: (10.1016/j.molcel.2016.09.024) Copyright © 2016 Elsevier Inc. Terms and Conditions