Tumor–eosinophil interactions.

Slides:

Advertisements

Similar presentations

Allergy and Hypersensitivity K. J. Goodrum Types of Immune Hypersensitivity Reactions.

Advertisements

Eosinophils Karen Buckland, Imperial College London, UK

Mononuclear phagocytes in Immune Defence

Eotaxin: a Potential Target for Therapy in Chronic Rhinosinusitis

OX40/OX40 Ligand Interactions in T-Cell Regulation and Asthma

Melanoma donor (MD) NK cells are functionally impaired/exhausted.

Heating is a multifunctional adjuvant that affects tumor microenvironment through several intrinsic and extrinsic mechanisms, which could enhance immunotherapy.

Eosinophilic Esophagitis: Is It All Allergies?

A (and inset), diffuse erythematous papules covering the back and upper extremities with histologic evidence of superficial perivascular dermatitis with.

Oncology Meets Immunology: The Cancer-Immunity Cycle

Stop Press: Eosinophils Drafted to Join the Th17 Team

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis Julia K. Gittler, BA, James G. Krueger,

Anti–IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL- 5 and IL-5 receptor levels Miguel L. Stein, MD, Joyce M. Villanueva,

Eosinophil extracellular DNA traps in skin diseases

by Emma Di Carlo, Guido Forni, PierLuigi Lollini, Mario P

A review of treatment with mepolizumab, an anti–IL-5 mAb, in hypereosinophilic syndromes and asthma William W. Busse, MD, Johannes Ring, MD, PhD, Johannes.

Laurence Zitvogel, Guido Kroemer Cancer Cell

Frequencies of immune cell types show much stronger variations between tumor types in the tumor infiltrate compared with the spleen and tumor-draining.

Tumor development of poorly immunogenic LLC and B16F10 cells modified to produce GM-CSF was markedly inhibited. Tumor development of poorly immunogenic.

Treatment of human MCC tumors with intralesional IFNβ is associated with MHC-I upregulation. Treatment of human MCC tumors with intralesional IFNβ is associated.

Functions of myeloid cells.

Biology and Treatment of Eosinophilic Esophagitis

Gr-1+ MDSC in tumor-bearing mice produce IL-6.

Mechanisms of immune escape in the tumor microenvironment.

Kinetic changes of sPD-L1 and cytokines, and kinetic radiographic reduction in tumor size after ipilimumab plus bevacizumab treatment. Kinetic changes.

Interactions of eosinophil granule proteins with skin

Comparison of cytokine profiles induced by ChiLob 7/4 and TLR ligands in ex vivo whole-blood stimulation assays. Comparison of cytokine profiles induced.

IL32 prompts cell activation and cancer-related pathways.

OX40/OX40 Ligand Interactions in T-Cell Regulation and Asthma

An Eosinophil Hypothesis for Functional Dyspepsia

The Tim-3 pathway in cancer.

Unstimulated levels of soluble mediators from in cultures of individuals with and without T2D with periodontitis. Unstimulated levels of soluble mediators.

Mechanisms of Contact Sensitization Offer Insights into the Role of Barrier Defects vs. Intrinsic Immune Abnormalities as Drivers of Atopic Dermatitis

Churg–Strauss syndrome

TGF-β1: Mediator of a feedback loop in eosinophilic esophagitis—or should we really say mastocytic esophagitis? J. Pablo Abonia, MD, James P. Franciosi,

Measurement of a) IL-8, b) IL-6 and c) GM-CSF release by BEAS-2B cells stimulated with deoxycholic acid for 48 h. Measurement of a) IL-8, b) IL-6 and c)

IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts Séverine Létuvé, PhD, Stéphane Lajoie-Kadoch, MSc, Séverine Audusseau,

Pathogenesis of allergic rhinitis

Yui-Hsi Wang, PhD, Simon P. Hogan, PhD, Patricia C

IL-13 induces eosinophil recruitment into the lung by an IL-5– and eotaxin-dependent mechanism Samuel M. Pope, BAa,b, Eric B. Brandt, PhDa, Anil Mishra,

Molecular and cellular mechanisms of allergic disease

Regulatory role of iNKT cells in T1D in humans and mice

Eosinophilic esophagitis: Pathogenesis, genetics, and therapy

CT-26 colon cancer induces the recruitment of protumor mast cells and the accumulation of MDSCs. CT-26 colon carcinoma cells (2 × 105) were injected s.c.

Adaptive NK cells resist immunosuppression in the tumor microenvironment. Adaptive NK cells resist immunosuppression in the tumor microenvironment. FACS-sorted.

Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the.

CD49b+ cells from tumor-bearing mice are more prone to conversion into MDSCs compared with naive CD49b+ cells. CD49b+ cells from tumor-bearing mice are.

IL32 is highly expressed in mycosis fungoides lesional skin.

CD11bhighCD27high conventional NK cells are converted into MDSCs

Protein expression profile in a dasatinib-resistant cell line.

IL6 mRNA is not detected in metastatic prostate cancer cells.

pDCs from the melanoma environment responded to TLR-L stimulation.

Model of the accumulation of Treg cells in human tumors.

Eosinophilic gastrointestinal disorders (EGID)

Supernatants of the positive proliferative responses indicated in Table 1 were analyzed for the presence of IFNγ, tumor necrosis factor-α, IL-2, IL-4,

Effect of anti-cyCD79b (10D10) and anti-cyCD79b (10D10)-MCC-DM1 on cytokine levels in cynomolgus monkeys. Effect of anti-cyCD79b (10D10) and anti-cyCD79b.

Expression of lnc-C/EBPβ in inflammation and in MDSCs induced by tumor-associated factors. Expression of lnc-C/EBPβ in inflammation and in MDSCs induced.

MDC/CCL22 and MMP-2 factors are found in the melanoma microenvironment and correlate with pDC accumulation and early relapse. MDC/CCL22 and MMP-2 factors.

PD-L1 is expressed in breast cancer.

Only IFNγ shows consistently increased mRNA expression in mycosis fungoides (MF) lesions. mRNA expression levels of various cytokines in the skin of healthy.

CPI-444 enhances T-cell activation in MC38 tumors.

Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.

Dgk inhibitors enhance the cytotoxic capacity of impaired human mesoCAR-transduced T cells. Dgk inhibitors enhance the cytotoxic capacity of impaired human.

Combination of R848 and anti-CD200R affects activation of tumor-infiltrating myeloid cells. Combination of R848 and anti-CD200R affects activation of tumor-infiltrating.

T cells with a ROR1-specific CAR eliminate tumor cells in vivo only with a modified long spacer. T cells with a ROR1-specific CAR eliminate tumor cells.

ADU-S100 primes the innate immune system in tolerant, tumor bearing neu/N mice. ADU-S100 primes the innate immune system in tolerant, tumor bearing neu/N.

Biopsies of the vaccination site were obtained 48 h after the first vaccination. Biopsies of the vaccination site were obtained 48 h after the first vaccination.

In situ expression of signature genes in the Th1, Th2, Th17, and Treg pathways. In situ expression of signature genes in the Th1, Th2, Th17, and Treg pathways.

Cell counts of immune infiltrate and expression of galectin-1 and galectin-3 in the short-, medium-, and long-term survival cohorts. Cell counts of immune.

Design and purification of CS1-NKG2D biAb by metal-affinity chromatography. Design and purification of CS1-NKG2D biAb by metal-affinity chromatography.

Presentation transcript:

Tumor–eosinophil interactions. Tumor–eosinophil interactions. Eosinophils infiltrate both the necrotic and fibrous capsules of tumors. Known tumor-associated cytokines related to eosinophil accumulation include IL-2, IL-3, IL-5, IL-25, GM-CSF, eotaxin-1, and HMGB1. Cellular contact and cytotoxicity have been shown for CD11a/CD18 and 2B4 and assumed for NKG2D. The granule proteins ECP, EDN, and MBP have been shown to be involved in tumor cytotoxicity following their release in tumors. Benjamin P. Davis, and Marc E. Rothenberg Cancer Immunol Res 2014;2:1-8 ©2014 by American Association for Cancer Research