Activation status of NK cells is associated with therapeutic effects of TKIs. PBMCs from CML patients were cocultured with HLA class I–deficient K562 cells.

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Activation status of NK cells is associated with therapeutic effects of TKIs. PBMCs from CML patients were cocultured with HLA class I–deficient K562 cells for 6 hours, and CD107a degranulation and intracellular IFNγ release from NK cells were analyzed by f... Activation status of NK cells is associated with therapeutic effects of TKIs. PBMCs from CML patients were cocultured with HLA class I–deficient K562 cells for 6 hours, and CD107a degranulation and intracellular IFNγ release from NK cells were analyzed by flow cytometry (E:T ratio 10:1). Representative plots from (A) patients who did and did not achieve MR4.0 are shown and (B and C) aggregated results are also plotted. Achieved MR4.0: n = 46; did not achieve MR4.0: n = 11). D and E, Data from patients segregated into male (n = 34) and female (n = 23) are also presented. Statistical comparisons were made using the Mann–Whitney test, and P < 0.05 were considered statistically significant. Hiroshi Ureshino et al. Cancer Immunol Res 2018;6:745-754 ©2018 by American Association for Cancer Research