Fig. 4 Age-specific immunity and transmission dynamics under two- and three-dose vaccine schedules. Age-specific immunity and transmission dynamics under.

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CsEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy.

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Presentation transcript:

Fig. 4 Age-specific immunity and transmission dynamics under two- and three-dose vaccine schedules. Age-specific immunity and transmission dynamics under two- and three-dose vaccine schedules. Waning vaccine-derived protection in the population raises the question of how additional vaccine doses would affect mumps transmission. To address this question, we evaluated several scenarios. (A) Cohorts over 40 years of age as of 2016 were exposed to endemic transmission before and shortly after vaccine rollout and likely retain life-long protection. However, a population protected only by two-dose vaccination would be expected to experience high prevalence of susceptibility over 20 years of age. (B and C) Our modeling suggests that the duration of protection can be extended through young adulthood by adding a third dose around 18 years of age, whereas routine booster doses every 10 or 20 years would be expected to sustain longer-term protection. Lines and shaded areas delineate median estimates and 95% CIs, respectively. (D) Under transmission dynamics estimated as of 2016, protection in young adult age groups achieved through the use of a third vaccine dose is expected to reduce the effective reproductive number (RE) below 1. We, however, predict RE to approach 1.10 under the two-dose schedule as cohorts that experienced high rates of mumps infection age out of the population; larger reductions in RE are sustained at higher coverage and with more frequent dosing. Colors are the same as in (A) to (C). R0, basic reproductive number. (E) In turn, these extensions of protection provide a stronger barrier against emergence of strains escaping vaccine immunity. A new strain with 8.5% (95% CI, 7.6 to 9.8%) probability of evading vaccine-induced immunity and infecting a vaccine-protected individual would be expected to succeed under a three-dose schedule with low coverage. We, however, estimate that a new strain would require 22.9% (95% CI, 16.4 to 29.7%) probability of infecting such an individual to emerge in a population with 88% uptake of the third dose and 10-year boosters. Lines denote 95% CIs, and shaded areas represent distributions around RE estimates. Joseph A. Lewnard and Yonatan H. Grad Sci Transl Med 2018;10:eaao5945 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works