Syrosingopine is synthetic lethal with mitochondrial ETC inhibition

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Fig. 3 Syrosingopine is synthetic lethal with mitochondrial ETC inhibition. Syrosingopine is synthetic lethal with mitochondrial ETC inhibition. (A) Proliferation assay of 6.5 cells treated with syrosingopine alone (blue lines) or in combination (red lines) with various mitochondrial inhibitors: piericidin A (1 nM), sodium malonate (30 mM), antimycin A (5 nM), sodium azide (1 mM), oligomycin (1 nM), and FCCP (10 μM). Data shown are non-normalized, and the y axis intercept shows the effect on cell growth of each mitochondrial inhibitor by itself in the absence of syrosingopine. (B) Immunoblot of 6.5, HL60, and OPM2 parental and ρ0-derived lines for mitochondrial genome–encoded MT-Co1 (mitochondrially encoded cytochrome c oxidase I). GAPDH, glyceraldehyde-3-phosphate dehydrogenase. (C) Proliferation assay of 6.5, HL60, and OPM2 parental cells (blue lines) and ρ0 derivatives (red lines), titrated with increasing concentrations of syrosingopine. Growth was measured after 3 days of treatment. Don Benjamin et al. Sci Adv 2016;2:e1601756 Copyright © 2016, The Authors