Clinical relevance of inhaled corticosteroids and HPA axis suppression

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Presentation transcript:

Clinical relevance of inhaled corticosteroids and HPA axis suppression Robert G. Dluhy, MD Journal of Allergy and Clinical Immunology Volume 101, Issue 4, Pages S447-S450 (April 1998) DOI: 10.1016/S0091-6749(98)70157-5 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Effect of budesonide (800 μg once daily),placebo, and fluticasone propionate (>FP; 250, 500, and 1000 μg once daily; 1000 μg twice daily) on 8-hour plasma cortisol levels in healthy volunteers. Reproduced with permission from Grahnen A. Eckermas SA, Brundin RM, Ling-Anderson A. An assessment of the systemic activity of single doses of inhaled fluticasone propionate in healthy volunteers. Br J Clin Pharmacol 1994;38:521-5, by Blackwell Science Ltd.). Journal of Allergy and Clinical Immunology 1998 101, S447-S450DOI: (10.1016/S0091-6749(98)70157-5) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of placebo, fluticasone propionate (FP; 100 and 500 μg twice daily), triamcinolone acetonide (TAA; 300 and 500 μg twice daily), and prednisone (Pred; 10 mg daily) on plasma cortisol levels in asthma patients (data on file, Glaxo Wellcome). Journal of Allergy and Clinical Immunology 1998 101, S447-S450DOI: (10.1016/S0091-6749(98)70157-5) Copyright © 1998 Mosby, Inc. Terms and Conditions