Fig. 1 RNA methyltransferase METTL14 and demethylase ALKBH5 promote growth and invasion of breast cancer cells. RNA methyltransferase METTL14 and demethylase.

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Fig. 1 RNA methyltransferase METTL14 and demethylase ALKBH5 promote growth and invasion of breast cancer cells. RNA methyltransferase METTL14 and demethylase ALKBH5 promote growth and invasion of breast cancer cells. Clonogenic assay on scrambled-siRNA– or METTL14-siRNA (METTL14 KD)–transfected (A) or ALKBH5-siRNA (ALKBH5 KD)–transfected (C) MDA-MB-231 cells. Bar graphs below show the number of colonies counted microscopically in 10 different fields. (B and D) Photomicrograph showing migrated (top) and invaded (bottom) MDA-MB-231 cells in scrambled (Scr) or METTL14 KD (B) or ALKBH5 KD (D) cells. Bar graphs show the number of migrated and invaded cells. The data shown are means ± SEM for at least three independent experiments. **P < 0.01; ***P < 0.001; ****P < 0.0001 versus control group, t test. (E and F) Photomicrographs showing representative tumor growth in nude mice injected with 2 × 106 scrambled-siRNA–transfected (control), METTL14-siRNA (METTL14 KD)–transfected (A), or ALKBH5-siRNA (ALKBH5 KD)–transfected (B) MDA-MB-231 cells mixed with Matrigel. Bar graphs show mean tumor volume for the control (n = 8), METTL14 KD (n = 8), and ALKBH5 KD (n = 8) groups at the end of the study on day 21 after implantation of the cells. Subbarayalu Panneerdoss et al. Sci Adv 2018;4:eaar8263 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).