Chemopreventive effect of bexarotene and budesonide on mouse SCLC

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Presentation transcript:

Chemopreventive effect of bexarotene and budesonide on mouse SCLC Chemopreventive effect of bexarotene and budesonide on mouse SCLC. A, experimental design of chemoprevention. Chemopreventive effect of bexarotene and budesonide on mouse SCLC. A, experimental design of chemoprevention. The time (vertical arrow) of Adeno-Cre virus administration was counted as week 0 (∼9 week-old). Chemopreventive agent (dotted line) or control (solid line) groups were administered 2 wk before Adeno-Cre (∼7 week-old). Mice were given the agent continuously until the end of the experiment (36 wk after Adeno-Cre virus; ∼45 week-old). B, chemopreventive effect of bexarotene and budesonide on mouse SCLC. Effect of bexarotene and budesonide treatments on mSCLC tumor incidence (a), SCLC tumor multiplicity (b), and SCLC tumor load (c). Columns, mean; bar, SE (*, P < 0.05). Yian Wang et al. Cancer Prev Res 2009;2:1059-1064 ©2009 by American Association for Cancer Research