Composite breakpoint map of 22q11, illustrating the relative locations of several atypical deletions, redrawn from fig 2 in Saitta et al.11 The common 3 Mb and the nested 1.5 Mb deletion are also shown, as well as the location of the LCR22 repeats at the proximal and distal VCFS breakpoints (filled boxes). Composite breakpoint map of 22q11, illustrating the relative locations of several atypical deletions, redrawn from fig 2 in Saitta et al.11 The common 3 Mb and the nested 1.5 Mb deletion are also shown, as well as the location of the LCR22 repeats at the proximal and distal VCFS breakpoints (filled boxes). Microsatellite markers and the PACs used for FISH characterisation of the deletion described in this paper are depicted, together with selected genes (boxed). S Garcia-Miñaur et al. J Med Genet 2002;39:e62 ©2002 by BMJ Publishing Group Ltd