On the Road to Bacterial Cell Death

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On the Road to Bacterial Cell Death Gerard D. Wright Cell Volume 130, Issue 5, Pages 781-783 (September 2007) DOI: 10.1016/j.cell.2007.08.023 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Common Mechanisms of Bacterial Cell Death Induced by Antibiotics Antibiotics bind to their targets, disrupting normal cellular metabolism, including the tricarboxylic acid (TCA) cycle. This depletes intracellular NADH, which is paired with a commensurate rise in the production of reactive oxygen species such as peroxide and superoxide. These reactive oxygen species interact with Fe2+ via Fenton chemistry to generate highly toxic oxygen radicals, which react with DNA and proteins, resulting in death of bacteria. Cell 2007 130, 781-783DOI: (10.1016/j.cell.2007.08.023) Copyright © 2007 Elsevier Inc. Terms and Conditions