Panobinostat induces reversible perturbations in PBMC gene expression patterns. Panobinostat induces reversible perturbations in PBMC gene expression patterns.

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Panobinostat induces reversible perturbations in PBMC gene expression patterns. Panobinostat induces reversible perturbations in PBMC gene expression patterns. (A) Venn diagram summarizing the number of differentially expressed genes (DEG) in comparisons between the indicated study visits. V2, baseline; V4, day 4 of panobinostat treatment; V12, follow-up. (B and C) Heat map (B) and principal-component analysis (C) of 428 transcripts differentially expressed between V2, V4, and V12. Data points from V2, V4, and V12 are indicated in orange, blue, and green, respectively. (D) R-Circos plot summarizing functional pathways enriched for DEGs. Outer circles reflect selected functional pathways and corresponding DEGs (PRBV, role of pattern recognition receptors; NFATIR, NFAT-dependent immune regulation; LES, leukocyte extravasation signaling; IL17S, IL-17 signaling; PI3KS, PI3K signaling; TREM1S, TREM1 signaling; IL8S, IL-8 signaling; fMLPS, fMLP signaling; TecKS, tec kinase signaling). Inner circles indicate levels of gene expression intensity (median gene z scores) of the respective transcripts at the indicated study visits. (E) Plasma IL-1β levels (in picograms per milliliter). A paired t test was performed, and the means of the results are depicted. Christel Rothe Brinkmann et al. mSphere 2018; doi:10.1128/mSphere.00616-17