Volume 53, Issue 4, Pages 780-787 (October 2010) HBV reactivation after fludarabine chemotherapy identified on investigation of suspected transfusion-transmitted Hepatitis B virus  J.P. Power, M. El Chaar, J. Temple, M. Thomas, D. Spillane, D. Candotti, J.P. Allain  Journal of Hepatology  Volume 53, Issue 4, Pages 780-787 (October 2010) DOI: 10.1016/j.jhep.2010.04.034 Copyright © 2010 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Phylogenetic tree of the pre-S/S region of Index, Patients 1 and 2 HBV strain compared to genotype D and other genotype strains. The phylogenetic tree was constructed with a 1420 nucleotide sequences in the pre-S/S region of HBV. Phylogenetic analysis was performed with the neighbour-joining algorithm based on Kimura two-parameter distance estimation method. Only bootstrap values ⩾75% are shown (1000 replicates). The GenBank accession numbers of Pro and Patients 1 and 2 are GU570523, GU570524, and GU570526, respectively. Journal of Hepatology 2010 53, 780-787DOI: (10.1016/j.jhep.2010.04.034) Copyright © 2010 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Amino acid sequence of the central part of MHR of three Irish genotype D patients and subgenotype D3 references. Index patient amino acid sequence is aligned against Patient 2 sequence used as wild type subgenotype D1 reference. Patient 1 appears possibly related to the index strain and shows similarities with but also considerable divergence from the index strain. Other subgenotype D3 reference strains are indicated by their GenBank accession number. Grey bars indicate antigenic loops 1–4 between cysteines 107 and 121, 121 and 124, 124 and 137, and 139 and 147, respectively. Journal of Hepatology 2010 53, 780-787DOI: (10.1016/j.jhep.2010.04.034) Copyright © 2010 European Association for the Study of the Liver Terms and Conditions