Elevated STAT3 phosphorylation and RANTES levels in tamoxifen-treated breast cancer cells. Elevated STAT3 phosphorylation and RANTES levels in tamoxifen-treated.

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Elevated STAT3 phosphorylation and RANTES levels in tamoxifen-treated breast cancer cells. Elevated STAT3 phosphorylation and RANTES levels in tamoxifen-treated breast cancer cells. A, activated STAT3 status of tamoxifen-treated T47D cells was examined. After treatment with 1 μmol/L tamoxifen for 2 weeks, T47D- and tamoxifen-treated T47D cells were harvested and lysates were subjected to Western blotting. RANTES secretion levels were then determined by ELISA. Columns, means of triplicate samples; bars, SD. *, P < 0.01. B, after RANTES treatment (50 ng/mL) for 2 weeks, cells were exposed to tamoxifen for 24 hours. Drug resistance levels were then determined by MTT assay. Columns, means of triplicate samples; bars, SD. *, P < 0.01, compared with control cells. C, ERα-positive primary breast cancer tissue slides were subjected to immunohistochemical staining for detection of pY-STAT3 and RANTES. D, the mechanism of maintenance of tamoxifen resistance is described. Eun Hee Yi et al. Mol Cancer Res 2013;11:31-42 ©2013 by American Association for Cancer Research