PREDICTION OF NOSOCOMIAL ACUTE-ON-CHRONIC LIVER FAILURE IN PATIENTS WITH CIRRHOSIS ADMITTED TO HOSPITAL WITH ACUTE DECOMPENSATION Giacomo Zaccherini,

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PREDICTION OF NOSOCOMIAL ACUTE-ON-CHRONIC LIVER FAILURE IN PATIENTS WITH CIRRHOSIS ADMITTED TO HOSPITAL WITH ACUTE DECOMPENSATION Giacomo Zaccherini, Maurizio Baldassarre, Michele Bartoletti, Manuel Tufoni, Sonia Berardi, Mariarosa Tamè, Lucia Napoli, Antonio Siniscalchi, Angela Fabbri, Lorenzo Marconi, Agnese Antognoli, Giulia Iannone, Marco Domenicali, Pierluigi Viale, Franco Trevisani, Mauro Bernardi, Paolo Caraceni JHEP Reports DOI: 10.1016/j.jhepr.2019.07.005 Copyright © 2019 Terms and Conditions

JHEP Reports DOI: (10.1016/j.jhepr.2019.07.005) Copyright © 2019 Terms and Conditions

Fig. 1 Patients with an acute decompensation of cirrhosis (AD) included in the analysis divided according to the presence of acute-on-chronic liver failure (ACLF) at study inclusion or the development of ACLF during hospital stay. JHEP Reports DOI: (10.1016/j.jhepr.2019.07.005) Copyright © 2019 Terms and Conditions

Fig. 2 Estimated probability of developing ACLF during hospitalization (solid line) and 95% confidence intervals (dotted lines) according to hemoglobin level (A), leucocyte count (B), and MELD score (C) at hospital admission. JHEP Reports DOI: (10.1016/j.jhepr.2019.07.005) Copyright © 2019 Terms and Conditions

Fig. 3 Cumulative incidence of Acute-on-Chronic Liver Failure (ACLF) during hospitalization in patients presenting none, 1, 2 or 3 risk factors at hospital admission, including hemoglobin level below 9.8g/dL, leucocyte count and MELD score above 5.59×109/L and 13 points respectively. JHEP Reports DOI: (10.1016/j.jhepr.2019.07.005) Copyright © 2019 Terms and Conditions

Fig. 4 Probability of the development of Acute-on-Chronic Liver Failure (ACLF) during hospitalization in patients presenting none 1, 2 or 3 risk factors according to the development of nosocomial infection during hospitalization. JHEP Reports DOI: (10.1016/j.jhepr.2019.07.005) Copyright © 2019 Terms and Conditions