miniMAVS, You Complete Me!

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miniMAVS, You Complete Me! Manira Rayamajhi, Edward A. Miao, Nathaniel J. Moorman Cell Volume 156, Issue 4, Pages 629-630 (February 2014) DOI: 10.1016/j.cell.2014.01.045 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Full-Length MAVS and miniMAVS Are Produced from a Single Bicistronic Message Full-length MAVS (MAVS) and miniMAVS are produced by a complex web of interlaced leaky-scanning events. Reinitiation after translation of uORF leads to production of the truncated miniMAVS, which inhibits the signal transduction pathway initiated by MAVS during viral infection. This inhibition appears to act as a negative feedback loop to limit MAVS signaling. Cell 2014 156, 629-630DOI: (10.1016/j.cell.2014.01.045) Copyright © 2014 Elsevier Inc. Terms and Conditions