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Volume 17, Issue 2, Pages 184-192 (February 2016) Wide versus narrow excision margins for high-risk, primary cutaneous melanomas: long- term follow-up of survival in a randomised trial Dr Andrew J Hayes, FRCS, Lauren Maynard, MSc, Gillian Coombes, RN, Prof Julia Newton-Bishop, FMedSci, Michael Timmons, FRCS, Prof Martin Cook, FRCPath, Jeffrey Theaker, FRCPath, Prof Judith M Bliss, MSc, J Meirion Thomas, FRCS The Lancet Oncology Volume 17, Issue 2, Pages 184-192 (February 2016) DOI: 10.1016/S1470-2045(15)00482-9 Copyright © 2016 Hayes et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile *Initial excision by the proposed pathway. †Initial excision by the alternative pathway. The Lancet Oncology 2016 17, 184-192DOI: (10.1016/S1470-2045(15)00482-9) Copyright © 2016 Hayes et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Overall survival (A) and melanoma-specific survival (B) HR=hazard ratio. The Lancet Oncology 2016 17, 184-192DOI: (10.1016/S1470-2045(15)00482-9) Copyright © 2016 Hayes et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Univariable subgroup analyses of overall survival (A) and melanoma-specific survival (B) The dotted line shows the hazard ratio for all patients. Data excludes patients with unknown values for each variable. TBT=total Breslow thickness. *95% CIs presented for all patients; 99% CIs presented for subgroups. The Lancet Oncology 2016 17, 184-192DOI: (10.1016/S1470-2045(15)00482-9) Copyright © 2016 Hayes et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Cumulative incidence for death due to melanoma (A) and death due to other causes (B) HR=hazard ratio. The Lancet Oncology 2016 17, 184-192DOI: (10.1016/S1470-2045(15)00482-9) Copyright © 2016 Hayes et al. Open Access article distributed under the terms of CC BY Terms and Conditions