Frequency of CD4+CD25+FoxP3+ and CD4+CD25+CD127low T cells in unactivated PBMCs from healthy donors. Frequency of CD4+CD25+FoxP3+ and CD4+CD25+CD127low.

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Frequency of CD4+CD25+FoxP3+ and CD4+CD25+CD127low T cells in unactivated PBMCs from healthy donors. Frequency of CD4+CD25+FoxP3+ and CD4+CD25+CD127low T cells in unactivated PBMCs from healthy donors. Frequency of FoxP3 expression in CD4+CD25+ T cells from one representative individual (A) and summary data from 8 healthy donors (B). Frequency of CD127low cells in CD4+CD25+ T cells from one representative individual (C, right upper panel) with summary data from 8 healthy donors (C, right lower panel) and frequency of FoxP3+ T cells in the CD4+CD25+CD127low population from one representative individual (C, left upper panel) with summary data from 8 healthy donors (C, left lower panel). Representative thymidine incorporation assay, which measured cell proliferation in the presence of media only, CD4+CD252 responder (R) cells plus CD4+CD25+CD127low suppressor (S) cells at R:S ratios of 0:1, 1:0, 1:0.1, 1:0.5, and 1:1 (D). Each experiment was performed in triplicate, and suppression assays were repeated with a minimum of 3 different donor samples. Bars represent mean ± SEM. Jingjing Sun et al. Cancer Discovery 2012;2:122-130 ©2012 by American Association for Cancer Research