Mitochondrial Fission: Rings around the Organelle Liza A. Pon  Current Biology  Volume 23, Issue 7, Pages R279-R281 (April 2013) DOI: 10.1016/j.cub.2013.02.042 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Model for mitochondrial fission. ER encircles mitochondria at sites of mitochondrial fission. INF2 that is associated with ER then stimulates polymerization of actin, which provides the force for partial constriction of the organelle. Drp1 assembles into spirals and cylinders at the constricted site, where it drives more constriction of the organelle and mitochondrial fission. Current Biology 2013 23, R279-R281DOI: (10.1016/j.cub.2013.02.042) Copyright © 2013 Elsevier Ltd Terms and Conditions