Different signaling pathways of TLR2, Nod, and TNFR1 in response to ligand, resulting in activation of NF-κB, the nuclear transcriptional factor responsible.

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Presentation transcript:

Different signaling pathways of TLR2, Nod, and TNFR1 in response to ligand, resulting in activation of NF-κB, the nuclear transcriptional factor responsible for regulation of the immune response genes (data from references 3, 113, and 194). Different signaling pathways of TLR2, Nod, and TNFR1 in response to ligand, resulting in activation of NF-κB, the nuclear transcriptional factor responsible for regulation of the immune response genes (data from references 3, 113, and 194). RIP1, receptor-interacting protein 1; FADD, Fas-associated death domain protein; TRAF2, TNF receptor-associated factor 2; PI3K, phosphatidylinositol 3-kinase composed of two subunits (p85 and p110). Bénédicte Fournier, and Dana J. Philpott Clin. Microbiol. Rev. 2005; doi:10.1128/CMR.18.3.521-540.2005