Flecainide-induced incessant orthodromic atrioventricular reentrant tachycardia in Wolff- Parkinson-White syndrome: Uneven depression of accessory pathway.

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Flecainide-induced incessant orthodromic atrioventricular reentrant tachycardia in Wolff- Parkinson-White syndrome: Uneven depression of accessory pathway.
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Tracing from a patient with Wolff–Parkinson–White (WPW) and documented supraventricular tachycardia. The first two cycles are preexcited and a 12-lead.
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Flecainide-induced incessant orthodromic atrioventricular reentrant tachycardia in Wolff- Parkinson-White syndrome: Uneven depression of accessory pathway conduction  Oscar A. Pellizzón, MD, PhD, Manlio F. Márquez, MD, Mario D. González, MD, Sebastián Nannini, MD, Rodolfo Leiva, MD, Antonia Catalano, MD, Pedro Iturralde, MD  HeartRhythm Case Reports  Volume 2, Issue 6, Pages 506-510 (November 2016) DOI: 10.1016/j.hrcr.2016.08.001 Copyright © 2016 Heart Rhythm Society Terms and Conditions

Figure 1 A: The 12-lead surface electrocardiogram before flecainide. B: Disappearance of antegrade conduction through the accessory pathway after the onset of flecainide. HeartRhythm Case Reports 2016 2, 506-510DOI: (10.1016/j.hrcr.2016.08.001) Copyright © 2016 Heart Rhythm Society Terms and Conditions

Figure 2 A: Supraventricular tachycardia before administration of flecainide with cycle length of 220 msec and interval RP of 80 msec. B: Incessant supraventricular tachycardia developed during flecainide administration. The RP interval has now increased to 120 msec. C: Following administration of intravenous adenosine there was transient termination of the tachycardia with rapid reinitiation in the absence of atrial or ventricular premature beats. Shortening of the sinus cycle length from 940 to 790 msec was enough to restart the tachycardia in the absence of premature beats. Arrows point to the retrograde P waves. Dotted lines indicate the R-P intervals. HeartRhythm Case Reports 2016 2, 506-510DOI: (10.1016/j.hrcr.2016.08.001) Copyright © 2016 Heart Rhythm Society Terms and Conditions

Figure 3 A: Electrocardiographic leads I, II, V1, and V5 are displayed along with electrograms recorded from the His bundle (HB), coronary sinus (CS), and right ventricle (RV) at a paper speed of 50 mm/sec. Pacing from proximal CS at a cycle length of 600 msec results in full preexcitation with negative delta wave in V1 and II consistent with a right inferior paraseptal accessory A-V pathway. After introducing a single extrastimulus with a coupling interval of 400 msec, antegrade block over the accessory A-V pathway allows exclusive antegrade conduction over the atrioventricular (AV) node and induction of an orthodromic AV reentrant tachycardia with a cycle length of 280 msec. B: Same recording as panel A (50 mm/sec) with fewer signals for clarity (leads V1 and V5, HB, and CS recordings). Earliest retrograde atrial activation was recorded from the proximal coronary sinus (CSp) owing to retrograde activation through the accessory A-V pathway. HeartRhythm Case Reports 2016 2, 506-510DOI: (10.1016/j.hrcr.2016.08.001) Copyright © 2016 Heart Rhythm Society Terms and Conditions