Biology of Blood and Marrow Transplantation

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Presentation transcript:

Biology of Blood and Marrow Transplantation CD101, “A Perfect Storm” Against Aspergillus: In Vitro Microbiology, in Vivo Tissue Distribution, and Front-Loaded Treatment and Prophylactic Efficacy in Mouse Disseminated and Pulmonary Aspergillosis Infection Models Voon Ong, Grayson Hough, Ken Bartizal, Abdul Sattar, Andrew Sharp, Pia Thommes Biology of Blood and Marrow Transplantation Volume 24, Issue 3, (March 2018) DOI: 10.1016/j.bbmt.2017.12.470 Copyright © 2017 Terms and Conditions

Figure 1 CD101 tissue distribution and associated half-lives in various organs. Biology of Blood and Marrow Transplantation 2018 24, DOI: (10.1016/j.bbmt.2017.12.470) Copyright © 2017 Terms and Conditions

Figure 2 Survival rate of mice given prophylaxis CD101 (5, 10, or 20 mg/kg) as a single dose prior to infection in disseminated aspergillosis. Biology of Blood and Marrow Transplantation 2018 24, DOI: (10.1016/j.bbmt.2017.12.470) Copyright © 2017 Terms and Conditions

Figure 3 Survival rate of mice given prophylaxis CD101 (5, 10, or 20 mg/kg) or micafungin (2 mg/kg) as a single dose one day prior to infection in pulmonary aspergillosis. Biology of Blood and Marrow Transplantation 2018 24, DOI: (10.1016/j.bbmt.2017.12.470) Copyright © 2017 Terms and Conditions