Octreotide (OCT) concentrations mixed with metoclopramide (MET) containing or not containing sodium bisulfate (SBS) for 10 days after being prepared. Octreotide.

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Octreotide (OCT) concentrations mixed with metoclopramide (MET) containing or not containing sodium bisulfate (SBS) for 10 days after being prepared. Octreotide (OCT) concentrations mixed with metoclopramide (MET) containing or not containing sodium bisulfate (SBS) for 10 days after being prepared. MET–SBS 0, Elieten (SBS free); MET–SBS 1.0, Primperan (SBS 1.09 mg/mL as sodium pyrosulfite 1 mg/mL). The initial concentrations (day 0) of each group were the calculated logical values. The percentages of OCT were calculated versus the initial concentrations. Open symbols represent groups in which no significant difference was noted throughout the 10-day period. Closed symbols represent groups in which a significant difference was noted during the 10-day period. *p<0.001 versus the OCT alone group on each day (one-way ANOVA followed by Tukey's post-hoc test). †The percentages of OCT were less than 90% versus the calculated logical initial OCT concentrations. Values are means±SEM (n=3). Kouichi Tanabe et al. Eur J Hosp Pharm 2015;22:171-175 ©2015 by British Medical Journal Publishing Group