Fig. 5 Minimal administration of ETL is tolerable and safe in mice.

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Fig. 5 Minimal administration of ETL is tolerable and safe in mice. Minimal administration of ETL is tolerable and safe in mice. To monitor the safety profile of ETL administration in mice, 12-week-old healthy BALB/c mice (n = 3 per group) were treated with three injections of PBS/CTRL or 50 μg of ETL. The time and mode of injections were identical to those specified for Fig. 3A. The mice were monitored and euthanized 24 hours after the final injection for the following analysis: (A) total mouse body weight, (B) relative liver weight, (C) relative organ weight (spleen, kidney, and heart), (D) white blood cell count, (E) total neutrophil count, (F) total lymphocyte count, (G) hemoglobin levels, and (H) platelet count in peripheral blood of mice (mean ± SEM; n = 3). (I) Serum biochemical profile in mice (serum was collected at 24 hours following the last injection; ALT, alanine aminotransferase; Creat, creatinine; BUN, blood urea nitrogen; AST, aspartate aminotransferase; Amyl, amylase; mean ± SEM; n = 3). Representative photomicrographs of spleen histology sections of (J) the splenic white pulp area and (K) the splenic red pulp area from the mice (n = 3). *P < 0.05. Nidhi Jyotsana et al. Sci Adv 2019;5:eaaw4197 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).