A variety of ROS1 gene fusions occur across multiple tumor types.

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A variety of ROS1 gene fusions occur across multiple tumor types. A variety of ROS1 gene fusions occur across multiple tumor types. A, schematic of oncogenic ROS1 fusions identified to date, illustrating 20 different 5′ gene fusion partners that rearrange with ROS1 in cancer. Exon variants are shown in brackets with gene names abbreviated to first letter. B, illustration of tumor types identified thus far that can harbor ROS1 gene fusions. GBM, glioblastoma multiforme; CRC, colorectal cancer. Anh T. Le, and Robert C. Doebele Cancer Discovery 2014;4:870-872 ©2014 by American Association for Cancer Research