Immediate allergic reactions to cephalosporins: Evaluation of cross-reactivity with a panel of penicillins and cephalosporins Cristina Antunez, PhD,

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Presentation transcript:

Immediate allergic reactions to cephalosporins: Evaluation of cross-reactivity with a panel of penicillins and cephalosporins Cristina Antunez, PhD, Natalia Blanca-Lopez, PhD, Maria Jose Torres, MD, PhD, Cristobalina Mayorga, PhD, Ezequiel Perez-Inestrosa, PhD, Maria Isabel Montañez, PhD, Tahia Fernandez, PhD, Miguel Blanca, MD, PhD Journal of Allergy and Clinical Immunology Volume 117, Issue 2, Pages 404-410 (February 2006) DOI: 10.1016/j.jaci.2005.10.032 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Metabolic transformation of the original cephalosporin molecule by the opening of the betalactam ring by an amino group of butylamine. Journal of Allergy and Clinical Immunology 2006 117, 404-410DOI: (10.1016/j.jaci.2005.10.032) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 General chemical structures of penicillin and cephalosporin molecules and chemical structures of the different betalactams used in this study. Journal of Allergy and Clinical Immunology 2006 117, 404-410DOI: (10.1016/j.jaci.2005.10.032) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 RAST inhibition assays of the different serum samples using discs bound to the culprit cephalosporin conjugated to PLL as the solid phase, and different betalactams conjugated to butylamine as the fluid phase. Journal of Allergy and Clinical Immunology 2006 117, 404-410DOI: (10.1016/j.jaci.2005.10.032) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions