Immunohistochemical determination of TIM-3 expression in ccRCC.

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Immunohistochemical determination of TIM-3 expression in ccRCC. Immunohistochemical determination of TIM-3 expression in ccRCC. A, the intensity of TIM-3 immunohistochemical staining was classified into three groups (score 0, 1, and 2). TIM-3+ immune cells are indicated as arrowheads. B, TIM-3 expression was weakly detected in renal tubules in noncancer kidney tissue. The Kaplan–Meier analysis of PFS (C) and OS (D) were performed to investigate the correlations between TIM-3 expression and clinical prognosis. E, the Kaplan–Meier analysis was performed in patients with lower stage (T1) or lower nuclear grade (grade 1 and 2). Yoshihiro Komohara et al. Cancer Immunol Res 2015;3:999-1007 ©2015 by American Association for Cancer Research